# Collagen, skin and GHK-Cu: the reading list

> The Nest Aesthetics reading list — The Nest Aesthetics reading list: published GHK-Cu and GHK research on collagen, skin penetration, tissue remodeling, gene data and a combination hair trial.

**Reading list**

The experiments and reviews that carry the arguments in these essays.

## Starting points

For the cellular starting point, the [human fibroblast collagen experiment](https://pubmed.ncbi.nlm.nih.gov/3169264/) would be my first stop. The [tissue-remodeling review](https://pubmed.ncbi.nlm.nih.gov/18644225/) widens the account to repair across the work it reviews.

The [review of topical GHK](https://pmc.ncbi.nlm.nih.gov/articles/PMC11830136/) addresses the delivery problem. Beside it sits the [human skin penetration experiment](https://pmc.ncbi.nlm.nih.gov/articles/PMC3016279/), where copper was measured in skin outside the body.

For a controlled human experiment, there is the [combination hair trial](https://pmc.ncbi.nlm.nih.gov/articles/PMC4969472/). The [gene-data review](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/) moves to a much wider scale, and rewards attention to the threshold attached to its headline figure.

## References

[1] Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ https://pubmed.ncbi.nlm.nih.gov/3169264/
[2] GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/
[3] Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective https://pmc.ncbi.nlm.nih.gov/articles/PMC11830136/
[4] Human skin penetration of a copper tripeptide in vitro as a function of skin layer https://pmc.ncbi.nlm.nih.gov/articles/PMC3016279/
[5] Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth https://pmc.ncbi.nlm.nih.gov/articles/PMC4969472/
[6] The human tri-peptide GHK and tissue remodeling https://pubmed.ncbi.nlm.nih.gov/18644225/
[7] Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/

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At Nest Aesthetics, published research into skin’s supporting tissue feeds my curiosity and these essays, with no clinical business here and no medical advice.